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Meta-analysis - maternal and paternal antidepressant use and the risk of neurodevelopmental disorders in offspring
A new meta-analysis involving 37 studies with almost 650,000 pregnancies exposed to antidepressants and 25,000,000 unexposed pregnancies has been published. Before adjusting for confounders, there was a small association between antidepressant use and the development of ADHD or autism in offspring, but this became non-significant once known confounders (e.g. maternal mental health issues) were taken into account. Please see the attached trial for full details.
Acetazolamide shortage - CPhA Guidance
The Canadian Society of Healthcare-Systems Pharmacy, Canadian Paediatric Society, and Canadian Ophthalmological Society have released a guidance document on the current acetazolamide shortage. Please see the attached document for full details.
Imipenem, cilastatin, and relebactam - Recarbrio - IV Monograph - updated May 2026
Mood Stabilizers in Hemodialysis - Lithium, Valproate, and Lamotrigine - Psychopharmacology Institute
The Psychopharmacology Institute has published an excellent article on mood stabilizers, including lithium, valproate, and lamotrigine, in hemodialysis. It provides a practical overview on the use of each. Please see the attached document for full details.